Whether considering a program for replication or preparing a program for replication by others, a number of key questions must be considered: What is the program intended to accomplish? Is the program effective? What makes it effective? Is the program ready to be replicated? What is the replication plan? This report draws on the replication experiences of three programs: Plain Talk, the Teen Outreach Program and the Children's Aid Society-Carrera Adolescent Pregnancy Prevention Program. It provides a brief overview of the primary issues involved in replicating a program to prevent teen pregnancy.