Substance abuse is America’s number one health problem touching the life of every family, congregation and community. While whites are the majority of drug users, black and Hispanic substance abusers suffer more of the consequences. Given the tremendous negative impact of substance abuse, this report outlines how researchers, policy makers and practitioners can stem the tide and help people recover. Research suggests religion may be a large part of the solution and this report explores that potential. Readers examine findings from the past and present, and review the relationship between race/ethnicity, substance abuse and spirituality. The document includes recommendations for clergy, foundations and researchers.